解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Smoothness is a hallmark of healthy movement. Past research indicates that smoothness may be a side product of a control strategy that minimizes error. However, this is not the only reason for smooth movements. Our musculoskeletal system itself contributes to movement smoothness: the mechanical impedance (inertia, dam...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00712.2015
更新日期:2017-03-01 00:00:00
abstract::Robust auditory perception plays a pivotal function for processing behaviorally relevant sounds, particularly with distractions from the environment. The neuronal coding enabling this ability, however, is still not well understood. In this study, we recorded single-unit activity from the primary auditory cortex (A1) o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00476.2016
更新日期:2017-02-01 00:00:00
abstract::Contusion-type injuries to the spinal cord are characterized by tissue loss and disruption of spinal pathways. Midcervical spinal cord injuries impair the function of respiratory muscles and may contribute to significant respiratory complications. This study systematically assessed the impact of a 100-kDy unilateral C...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00727.2016
更新日期:2017-02-01 00:00:00
abstract::While the effects of sensory feedback on bimanual tasks have been studied extensively at two ends of the motor control hierarchy, the cortical and behavioral levels, much less is known about how it affects the intermediate levels, including neural control of homologous muscle groups. We investigated the effects of som...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00269.2016
更新日期:2017-02-01 00:00:00
abstract::An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson (J Neurophysiol 114: 1713-1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as be...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.01065.2015
更新日期:2017-02-01 00:00:00
abstract::GSG1L is an AMPA receptor (AMPAR) auxiliary subunit that regulates AMPAR trafficking and function in hippocampal CA1 pyramidal neurons. However, its physiological roles in other types of neurons remain to be characterized. Here, we investigated the role of GSG1L in hippocampal dentate granule cells and found that GSG1...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00307.2016
更新日期:2017-01-01 00:00:00
abstract::Itch is often triggered by warming the skin in patients with itchy dermatitis, but the underlying mechanism is largely unknown. We presently investigated if warming the skin enhances histamine- or serotonin (5-HT)-evoked itch behavior or responses of sensory dorsal root ganglion (DRG) cells, and if responses of superf...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00703.2016
更新日期:2017-01-01 00:00:00
abstract::Our understanding of how we learn and retain motor behaviors is still limited. For instance, there is conflicting evidence as to whether the memory of a learned visuomotor perturbation consolidates; i.e., the motor memory becomes resistant to interference from learning a competing perturbation over time. Here, we soug...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00178.2016
更新日期:2017-01-01 00:00:00
abstract::Visual search is a ubiquitous visual behavior, and efficient search is essential for survival. Different cognitive models have explained the speed and accuracy of search based either on the dynamics of attention or on similarity of item representations. Here, we examined the extent to which performance on a visual sea...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00569.2016
更新日期:2017-01-01 00:00:00
abstract::Damage to the peripheral vestibular system can result in debilitating postural, perceptual, and visual symptoms. A potential new treatment for this clinical problem is to replace some aspects of peripheral vestibular function with an implant that senses head motion and provides this information to the brain by stimula...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00601.2016
更新日期:2016-12-01 00:00:00
abstract::Understanding how the brain processes sensory input to generate behavior remains an important problem in neuroscience. Towards this end, it is useful to compare results obtained across multiple species to gain understanding as to the general principles of neural coding. Here we investigated hindbrain pyramidal cell ac...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00594.2016
更新日期:2016-12-01 00:00:00
abstract::Recording simultaneous activity of a large number of neurons in distributed neuronal networks is crucial to understand higher order brain functions. We demonstrate the in vivo performance of a recently developed electrophysiological recording system comprising a two-dimensional, multi-shank, high-density silicon probe...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00318.2016
更新日期:2016-11-01 00:00:00
abstract::Long-train electrical stimulation of the motor and premotor cortices of nonhuman primates can produce either hand-to-mouth or grasp-to-inspect movements, depending on the precise location of stimulation. Furthermore, single-neuron recording studies identify discrete neuronal populations in the inferior parietal and ve...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00222.2016
更新日期:2016-11-01 00:00:00
abstract::The aim of this study was to investigate how maximal intermittent contractions for a hand muscle influence cortical and reflex activity, as well as the ability to voluntarily activate, the homologous muscle in the opposite limb. Twelve healthy subjects (age: 24 ± 3 years, all right hand dominant) performed maximal con...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00367.2016
更新日期:2016-11-01 00:00:00
abstract::Optogenetic activation of axons is a powerful approach for determining the synaptic properties and impact of long-range projections both in vivo and in vitro. However, because of the difficulty of measuring activity in axons, our knowledge of the reliability of optogenetic axonal stimulation has relied on data from so...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00456.2016
更新日期:2016-11-01 00:00:00
abstract::Astrocyte-derived lactate supports pathologically enhanced neuronal metabolism, but its role under physiological conditions is still a matter of debate. Here, we determined the contribution of astrocytic neuronal lactate shuttle for maintenance of ion homeostasis and energy metabolism. We tested for the effects of α-c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00327.2016
更新日期:2016-11-01 00:00:00
abstract::Patch clamp is the main technique for measuring electrical properties of individual cells. Since its discovery in 1976 by Neher and Sakmann, patch clamp has been instrumental in broadening our understanding of the fundamental properties of ion channels and synapses in neurons. The conventional patch-clamp method requi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00386.2016
更新日期:2016-10-01 00:00:00
abstract::In the ventral tegmental area (VTA), interactions between dopamine (DA) and γ-aminobutyric acid (GABA) neurons are critical for regulating DA neuron activity and thus DA efflux. To provide a mechanistic explanation of how GABA neurons influence DA neuron firing, we developed a circuit model of the VTA. The model is ba...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00232.2016
更新日期:2016-10-01 00:00:00
abstract::Retinal degeneration (rd) leads to progressive photoreceptor cell death, resulting in vision loss. Stimulation of the inner-retinal neurons by neuroprosthetic implants is one of the clinically approved vision-restoration strategies, providing basic visual percepts to blind patients. However, little is understood as to...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01095.2015
更新日期:2016-10-01 00:00:00
abstract::Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) enables noninvasive neurophysiological investigation of the human cortex. A TMS paradigm of short-latency afferent inhibition (SAI) is characterized by attenuation of the motor-evoked potential (MEP) and modulation of N100 of the TMS-evoke...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00260.2016
更新日期:2016-09-01 00:00:00
abstract::Weight predictions used to scale lifting forces adapt quickly when repeatedly lifting unusually weighted objects and are readily updated by explicit information provided about weight. In contrast, weight predictions used when making perceptual judgments about weight are more resistant to change and are largely unaffec...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01051.2015
更新日期:2016-09-01 00:00:00
abstract::Norepinephrine (NE) is a potent modulator of breathing that can increase/decrease respiratory activity by α1-/α2-adrenergic receptor (AR) activation, respectively. The retrotrapezoid nucleus (RTN) is known to contribute to central chemoreception, inspiration, and active expiration. Here we investigate the sources of c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00023.2016
更新日期:2016-09-01 00:00:00
abstract::Mechanisms that could mitigate the effects of hypoxia on neuronal signaling are incompletely understood. We show that axonal performance of a locust visual interneuron varied depending on oxygen availability. To induce hypoxia, tracheae supplying the thoracic nervous system were surgically lesioned and action potentia...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00354.2016
更新日期:2016-09-01 00:00:00
abstract::The functional role of input from the primary motor cortex (M1) to primary somatosensory cortex (S1) is unclear; one key to understanding this pathway may lie in elucidating the cell-type specific microcircuits that connect S1 and M1. Recently, we discovered that a subset of pyramidal neurons in the infragranular laye...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01032.2015
更新日期:2016-09-01 00:00:00
abstract::The input-output and discharge properties of neurons are shaped by both passive and active electrophysiological membrane properties. Whole cell patch-clamp recordings in lamina I-III neurons in an isolated preparation of the whole spinal cord of juvenile rats with attached dorsal roots and dorsal root ganglia were use...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00187.2016
更新日期:2016-09-01 00:00:00
abstract::Following peripheral nerve injury, moderate daily exercise conducted on a level treadmill results in enhanced axon regeneration and modest improvements in functional recovery. If the exercise is conducted on an upwardly inclined treadmill, even more motor axons regenerate successfully and reinnervate muscle targets. W...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00129.2016
更新日期:2016-09-01 00:00:00
abstract::Inhibition is presumed to play an important role in gustatory processing in the rostral nucleus of the solitary tract (rNST). One source of inhibition, GABA, is abundant within the nucleus and comes both from local, intrasolitary sources and from outside the nucleus. In addition to the receptor-mediated effects of GAB...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00168.2016
更新日期:2016-08-01 00:00:00
abstract::The problem of how the hippocampus encodes both spatial and nonspatial information at the cellular network level remains largely unresolved. Spatial memory is widely modeled through the theoretical framework of attractor networks, but standard computational models can only represent spaces that are much smaller than t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00856.2015
更新日期:2016-08-01 00:00:00
abstract::The process of sensorimotor adaptation is considered to be driven by errors. While sensory prediction errors, defined as the difference between the planned and the actual movement of the cursor, drive implicit learning processes, target errors (e.g., the distance of the cursor from the target) are thought to drive exp...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00830.2015
更新日期:2016-08-01 00:00:00
abstract::Traditional electrophysiological research on invertebrate photoreceptors has been conducted in vivo, using intracellular recordings from intact compound eyes. The only exception used to be Drosophila melanogaster, which was exhaustively studied by both intracellular recording and patch-clamp methods. Recently, several...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00288.2016
更新日期:2016-08-01 00:00:00
abstract::There is evidence that postural instability associated with Parkinson's disease (PD) is not adequately improved by levodopa, implying involvement of nondopaminergic pathways. However, the mechanisms contributing to postural instability have yet to be fully identified and tested for their levodopa responsiveness. In th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00996.2015
更新日期:2016-08-01 00:00:00
abstract::Many rapidly firing neurons, including those in the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now descr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00174.2016
更新日期:2016-07-01 00:00:00
abstract::Skeletal muscle force can be transmitted to the skeleton, not only via its tendons of origin and insertion but also through connective tissues linking the muscle belly to surrounding structures. Through such epimuscular myofascial connections, length changes of a muscle may cause length changes within an adjacent musc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00937.2015
更新日期:2016-06-01 00:00:00
abstract::Sensory-driven behaviors engage a cascade of cortical regions to process sensory input and generate motor output. To investigate the temporal dynamics of neural activity at this global scale, we have improved and integrated tools to perform functional imaging across large areas of cortex using a transgenic mouse expre...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01056.2015
更新日期:2016-06-01 00:00:00
abstract::Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor (GABABR...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00535.2015
更新日期:2016-06-01 00:00:00
abstract::Synchronization between the firing times of simultaneously active motor units (MUs) is generally assumed to increase during fatiguing contractions. To date, however, estimates of MU synchronization have relied on indirect measures, derived from surface electromyographic (EMG) interference signals. This study used intr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00097.2016
更新日期:2016-06-01 00:00:00
abstract::We demonstrate distinct α- (7-14 Hz) and β-band (15-30 Hz) rhythms in rat somatosensory cortex in vivo using epidural electrocorticography recordings. Moreover, we show in rats that a genuine β-rhythm coexists alongside β-activity that reflects the second harmonic of the arch-shaped somatosensory α-rhythm. This demons...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00507.2015
更新日期:2016-06-01 00:00:00
abstract::Visual response properties of neurons in the dorsolateral geniculate nucleus (dLGN) have been well described in several species, but not in rats. Analysis of responses from the unanesthetized rat dLGN will be needed to develop quantitative models that account for visual behavior of rats. We recorded visual responses f...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00812.2014
更新日期:2016-06-01 00:00:00
abstract::The action potential (AP) is a fundamental feature of excitable cells that serves as the basis for long-distance signaling in the nervous system. There is considerable diversity in the appearance of APs and the underlying repolarization mechanisms in different neuronal types (reviewed in Bean BP. Nat Rev Neurosci 8: 4...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01028.2015
更新日期:2016-05-01 00:00:00
abstract::Impairments in human motor patterns are complex: what is often observed as a single global deficit (e.g., limping when walking) is actually the sum of several distinct abnormalities. Motor adaptation can be useful to teach patients more normal motor patterns, yet conventional training paradigms focus on individual fea...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00090.2016
更新日期:2016-05-01 00:00:00